7 Sept 2025, 08:56 UTC≈1,340 views7 reactionsread 26 August 2026 THROMBOLYTIC THERAPY
Thrombolytic/Fibrinolytic Agents are often referred to as Tissue Plasminogen Activators which cleave Plasminogen into active Plasmin, which will then lyse the fibrin matrix
OVERVIEW OF MECHANISM OF ACTION
Fibrinolytic agents are subdivided based on their MoAs:
— Fibrin-specific: Require presence of Fibrin to be able to convert Plasminogen into active Plasmin
— Non-Fibrin-specific: Do not need f…
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16 Jul 2025, 23:10 UTC≈1,290 views3 reactionsread 26 August 2026 Photo
🦠Diagnosis and Treatment of Community-Acquired Pneumonia🦠
📊Flowchart in CAP Algorithm
Diagnosis of CAP: Fever + Cough, Obtain Vital Signs, Check PE for Crackles, Dullness → STRATIFY as LR/MR/HR → Treat accordingly
📊RISK STRATIFICATION
👉CAP-Low Risk: Stable Vital Signs, Stable or Absent Comorbids - No signs of acutely altered sensorium: DISCHARGE AS OPD
👉CAP-Moderate Risk: Unstable Vital Signs, Unstable Comorbids, …
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16 Jul 2025, 22:26 UTC≈1,050 views2 reactionsread 26 August 2026 Photo
🫁ARDS Diagnostic Criteria: 2012 Berlin Definition versus the New 2023 Global Definition🫁
👉Acute Respiratory Distress Syndrome is a clinical syndrome characterized by severe, rapid-onset Dyspnea, hypoxemia, and Diffuse Infiltrates resulting in Respiratory Failure.
👉Minimum Diagnostics to Diagnose ARDS in the COMMUNITY SETTING (Kigali Criteria): Physical Exam, CXR AP/POCUS, Pulse Oximeter (Desat at 97 and below)
REF…
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3 Jul 2025, 12:33 UTC≈1,100 views8 reactionsread 26 August 2026 Photo
According to the meta-analysis of Gogos, et al., 2024, which pooled data from 8 studies comparing DOACs vs VKAs in their efficacy and safety profile, here are the following results (Gogos, et al., 2024):
— DOACs have 54% lower risk of significant bleeding vs VKAs (Pooled OR: 0.46 p=0.01)
— DOACs have 70% lower risk of producing systemic embolism compared to VKAs (Pooled OR: 0.3, p=0.01)
— DOACs have about twofold hig…
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30 Jun 2025, 09:57 UTC≈1,070 views4 reactionsread 26 August 2026 Photo
🩸Triple Anticoagulation Therapy among STEMI patients in LV Thrombus prevention🩸
Lifted from Zhang, et al., 2022
According to the study of Zhang, et al., the addition of low-dose (2.5mg BID) Rivaroxaban can prevent LV Thrombus formation among patients with Anterior STEMI who underwent Interventional treatments when compared with DAPT alone.
Albeit Triple Anticoagulation Therapy will significantly increase bleeding …
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21 May 2025, 02:54 UTC≈1,150 viewsread 26 August 2026 Photo
🩸Prevention of Stroke for Patients with Atrial Fibrillation (AHA 2023)🩸
Note: Atrial Fibrillation promotes stroke and cardioembolic complications
— Patients with Atrial Fibrillation should be evaluated for risk of thromboembolism via validated clinical risk scores such as CHA2DS2-VASc
— Patients should also be evaluated for risk for bleeding via Risk scores such as HAS-BLED or HEMORR2HAGES or Neuro clearance, in the…
19 May 2025, 17:00 UTC≈1,040 views4 reactionsread 26 August 2026 Photo
Secondary Lifestyle Prevention For Atrial Fibrillation focuses on the following:
— Obesity
— Physical Inactivity
— Tobacco Use
— Alcohol Consumption
— Hypertension
— Sleep Disordered Breathing/OSA (May offer conditionally)
Note: Caffeine abstinence has no effect on Atrial Fibrillation symptoms but may be avoided for patient who report it as triggers ❤️
Source: AHA 2023 Guidelines for Atrial Fibrillation
https://www…
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19 May 2025, 16:57 UTC866 viewsread 26 August 2026 File
File, posted without a caption
19 May 2025, 16:57 UTC960 views1 reactionsread 26 August 2026 Photo
📺Screening Modalities for Atrial Fibrillation📺
— Once noted by C2HEST Screening Tool to have increased risk for Atrial Fibrillation, patients are recommended to have initial Lifestyle and Risk Factor Modification as part of management which targets Obesity, Physical Inactivity, Alcoholism, Smoking, Diabetes, and Hypertension
— Most CV Risk Factors associated with increased risk of new-onset Atrial Fibrillation hen…
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30 Dec 2024, 13:41 UTC≈1,930 views16 reactionsread 26 August 2026 Photo
CAP Risk Stratification
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30 Dec 2024, 13:41 UTC≈1,870 viewsread 26 August 2026 D. Empiric Treatment for CAP-MR/HR with MDRO isolates
1. MRSA Risk Factors and Treatment
- Risk Factors: Prior colonization or infection with MRSA within 1 year and IV Antibiotic therapy in the last 90 days
- Treatment:
- Nonpseudomonal Beta-lactam + Macrolide/Respiratory Fluoroquinolone + Vancomycin/Linezolid/Clindamycin
- Ampicillin-sulbactam 1.5-3g QID or Cefotaxime 1-2g IV TID or Ceftriaxone 1-2g IV O…
30 Dec 2024, 13:41 UTC≈1,300 views3 reactionsread 26 August 2026 Approach to Community Acquired Pneumonia
Risk Stratification for CAP
CAP-LR: Fever + Crackles + Stable/Absent Comorbids + Stable Vital Signs
CAP-MR: Fever + Crackles + Uncontrolled Comorbids + Unstable Vital Signs
CAP-HR: Fever + Crackles + Shock and Need For Assisted Ventilation
Diagnostic Workup for Community-Acquired Pneumonia
1. Sputum GSCS
- Not recommended for workup of CAP-LR since Empiric Treatment already c…
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