❗️ В рамках V Международного форума «Содружество без границ» открыт прием тезисов! Впервые участники Форума смогут представить результаты фундаментальных и клинических исследований, описание клинических случаев, а также материалы, отражающие практический опыт в области диагностики, лечения и сопровождения пациентов с наследственными орфанными заболеваниями 🗓Срок подачи тезисов: с 3 августа по 30 сентября 2026 года …

Channel
Significo-АМГ
@significogene
On this record: Growth · Engagement · Reactions · Posts · Posts edited after publishing · Polls · Citations · Telegram's recommendations · Cite this entry
5,746subscribers
-37 since we began measuring on 6 August 2026
Risers and fallers across the register · movement among entries of 3,162–10,000.
Register entry
| Telegram ID | -1001764622779 |
|---|---|
| Type | Channel |
| Username | @significogene |
| Created | 12 March 2022 — measured — cross-checked against a third-party dataset (ext.tg_channel) |
| First recorded | 6 August 2026 |
| Last confirmed live | 10 September 2026 |
| Measurements held | 12 |
| Confirmed unchanged | 1 time, most recently 10 September 2026 |
| On Telegram | t.me/significogene |
Growth
| Measured (UTC) | Subscribers | Change |
|---|---|---|
| 10 Sept 2026, 07:16 | 5,746 | +4 |
| 4 Sept 2026, 23:19 | 5,742 | -4 |
| 1 Sept 2026, 12:04 | 5,746 | -3 |
| 29 Aug 2026, 19:45 | 5,749 | -5 |
| 26 Aug 2026, 14:43 | 5,754 | -4 |
| 23 Aug 2026, 23:14 | 5,758 | -8 |
| 19 Aug 2026, 21:15 | 5,766 | -3 |
| 16 Aug 2026, 21:08 | 5,769 | -5 |
| 13 Aug 2026, 12:27 | 5,774 | -2 |
| 10 Aug 2026, 12:52 | 5,776 | -8 |
| 7 Aug 2026, 02:57 | 5,784 | +1 |
| 6 Aug 2026, 19:15 | 5,783 | first reading |
Engagement
32 posts held, back to 24 July 2026 — the reader has not yet reached the start of this channel’s public history, so older posts may sit further back, unread. Read across 9 pages of Telegram’s post history, 20 posts per page.
Nothing published in the last 30 days. ERR and ER are rolling 30-day measures, so there is nothing to compute — we hold 32 posts for this entry, the most recent from 11 August 2026. An engagement rate over an empty window would be a number about nothing.
Reaction mix
320 reactions across 31 posts, in 17 distinct kinds. The most used accounts for 30.3% of them.
| Reaction | Count | Share | Share, drawn |
|---|---|---|---|
| 👍 | 97 | 30.3% | |
| ❤ | 83 | 25.9% | |
| 🔥 | 49 | 15.3% | |
| ✍ | 22 | 6.88% | |
| ⚡ | 13 | 4.06% | |
| 🗿 | 11 | 3.44% | |
| 😢 | 11 | 3.44% | |
| 🤔 | 11 | 3.44% | |
| 😱 | 4 | 1.25% | |
| 🙏 | 4 | 1.25% | |
| 👌 | 3 | 0.938% | |
| 🤓 | 3 | 0.938% | |
| 👀 | 2 | 0.625% | |
| 💯 | 2 | 0.625% | |
| 🥰 | 2 | 0.625% | |
| 🦄 | 2 | 0.625% | |
| 👏 | 1 | 0.313% |
No sentiment is inferred, and none should be read in. This table is ordered by count and by nothing else. Emoji do not carry stable meaning across languages or communities — 🙏 is thanks in one channel and mourning in another — so we publish which ones were pressed and how often, and pass no judgement on what an audience meant by them.
Precision. Telegram publishes reaction counts per emoji and short-forms each one — 4.34K, 1.2M — so any single kind at or above 1,000 reaches us at three significant figures, and only counts below 1,000 are exact. The shares above are ratios of those figures and carry the same error. This is also why the total here can differ slightly from a reaction total printed elsewhere on the page: both are sums of the same rounded parts, taken over samples with different edges.
Coverage. Reactions were read on 31 of the 32 sampled posts in this sample. Summed by Telegram’s own count on each post — not by adding up the per-emoji breakdown above — those same posts carry 320 reactions in total: the kind of figure the paragraph above means by “a reaction total printed elsewhere on the page”.
Measured over the 32 most recent posts we hold, published 24 July 2026 to 11 August 2026, using the newest reading held for each. Telegram Stars are excluded: they are a payment, not a reaction, and they have their own section.
Recent posts
В Nature опубликованы результаты масштабного исследования трехмерных моделей опухолей. С помощью полногеномного CRISPR-скрининга исследователи выявили потенциальные терапевтические мишени, которые могут оставаться незамеченными при использовании традиционных клеточных линий https://www.nature.com/articles/s41586-026-10843-7
❤4✍3👍2
По мнению гендиректора компании «Право на здоровье» Ольги Макаркиной, одобрение отечественного препарата веренафусп альфа для пациентов с синдромом Хантера может свидетельствовать в пользу общего курса регулятора на повышение доступности инновационных лекарств https://www.kommersant.ru/doc/8876579?query=%D0%9E%D1%80%D1%84%D0%B0%D0%BD%D0%BD%D1%8B%D0%B5
❤5🙏2
Исследователи НИУ ВШЭ разработали ИИ-модель для создания промоторов и энхансеров, которая работает непосредственно с нуклеотидными последовательностями ДНК. Подход показал результаты, сопоставимые с ведущими генеративными моделями, и в перспективе может применяться для проектирования регуляторных элементов с заданными свойствами https://companies.rbc.ru/news/5yzOq9jrEq/issledovateli-vshe-pokazali-kak-sozdavat-regulya…
❤6👍4✍2
Insilico Medicine объявила о старте III фазы клинических испытаний препарата rentosertib (ISM001-055), потенциально первого в своем классе перорального ингибитора TNIK для лечения идиопатического легочного фиброза https://insilico.com/news/xmjsn4l091-insilico-initiates-phase-iii-clinical-tr
👍5
8 августа — День осведомленности о синдроме CHARGE https://asi.org.ru/2026/08/08/kira-polnostyu-opravdyvaet-svoj-charge-sindrom/
❤7
В Минздраве одобрили еще пять лекарств для перечня ЖНВЛП. В список могут попасть препараты от рака молочной железы, гепатита C, синдрома Хантера, меланомы кожи и некоторых видов рака легкого https://tass.ru/obschestvo/27993531
👍5
#дайджест Первая РНК-терапия наследственной кардиомиопатии, положительные результаты клеточной терапии при миодистрофии Дюшенна и новые вопросы безопасности генной терапии: главные новости лечения орфанных заболеваний за июль 🧬 Минздрав РФ зарегистрировал таблетированную форму препарата рисдиплам компании Roche для лечения спинальной мышечной атрофии (СМА) https://tass.ru/ekonomika/27890531 🧬 Стартовала I/IIa фаза…
❤8👍2🔥2
Дорогие друзья! Открыта регистрация на юбилейный V Международный форум по диагностике и лечению наследственных орфанных болезней «Содружество без границ» 🗓️ 29–30 октября 2026 года 📍Самарканд, Республика Узбекистан 🌍 Ежегодно Форум объединяет более 5 000 специалистов со всего мира. В этом году в мероприятии примут участие эксперты из Азербайджана, Беларуси, Бельгии, Великобритании, Грузии, Израиля, Италии, Казахс…
🔥8👍6❤2
Отечественные ученые разрабатывают мультиплексную ПЦР-панель для фармакогенетического тестирования при индивидуальном подборе антидепрессантов пациентам https://gxpnews.net/2026/08/v-rossii-pristupili-k-razrabotke-geneticheskogo-testa-dlya-podbora-antidepressantov-po-dnk/?utm_source=yxnews&utm_medium=desktop&utm_referrer=https%3A%2F%2Fdzen.ru%2Fnews%2Fsearch
👍6🤓3🔥2
Минздрав РФ представил проект с изменениями Порядка приобретения лекарств и медизделий для детей с тяжелыми жизнеугрожающими, хроническими и редкими (орфанными) заболеваниями. Решение позволит регламентировать передачу незарегистрированных препаратов и информировать об этом госфонд «Круг добра». Для этого предлагается погружать в ЕГИСЗ сведения о передаче и введении таких лекарств пациенту https://vademec.ru/news/20…
👍3✍1
Ученые представили специализированную ИИ-систему, способную анализировать биомедицинские данные, формулировать научные гипотезы о механизмах заболеваний и потенциальных терапевтических мишенях. Обученная на 24,4 млн научных публикаций и 613 ТБ биомедицинских данных, система предложила новые мишени при болезни Паркинсона (CHK2 и IRAK4), а экспериментальное ингибирование CHK2 подтвердило её прогноз, уменьшив потерю доф…
❤6⚡5👍4😱1
Showing the 12 most recent of 32 posts we hold for @significogene. View and reaction counts are the latest single reading for each post, not a live figure, and a recent post is still accumulating both. A view count marked ≈ was rounded by Telegram before we ever saw it — t.me prints views in full below 1,000 and to three significant figures above, so ≈1,200,000 means somewhere between 1,150,000 and 1,249,999. Unmarked counts are exact. Text is reproduced from the public post preview and truncated for length.
Posts edited after publishing
@significogene edited 1 post after it first published — the same permalink now carries different wording than the one this register originally read, caught because our own crawl held a copy of the earlier text.
An edit is not deception. Typo fixes, price updates and corrections look exactly like this too — this register can tell you the wording changed and when, not why. How this is measured.
- First edit seen
- 10 August 2026
- Most recent edit
- 10 August 2026
Polls
The poll we hold for this entry, as Telegram rendered it when we read the post. A poll’s figures keep moving after that, so each one is dated.
Выберите наиболее верные утверждения
- Повышения ферритина в крови достаточно для подтверждения диагноза13%
- Результатов ДНК-диагностики достаточно для подтверждения диагноза63%
- Суставные симптомы относятся к сопутствующей ненаследственной патологии13%
- Сахарный диабет и гипогонадизм следствия одного патологического процесса59%
- Флеботомия позволяет профилактировать необратимые осложнения22%
- Отсутствие неврологических симптомов исключает нарушения обмена меди20%
- Отсутствие эмфиземы легких исключает дефицит а1-антитрипсина как причину поражения печени20%
- Хелаторы железа не являются первой линией терапии33%
- После нормализации б/х маркеров лечение может быть остановлено11%
The shares total 254%, above 100: this poll accepts more than one answer per voter. No per-option vote count is published, so the number of voters who chose each option is not derivable and is not shown.
Percentages only — there are no per-option vote counts here, because Telegram publishes none. The public post preview gives each option’s share and a single voter total, and nothing else. Multiplying one by the other would produce a per-option tally that looks measured and is not: the shares are rounded to whole numbers before we ever see them. We print what was published and leave the column that does not exist empty.
The shares need not add up to 100. Rounding alone puts many polls at 99 or 101. A poll that allows more than one answer per voter runs well past 100 by design, and several here do. The bars are drawn against a fixed 100% track at each option’s own percentage rather than normalised to the total, so a poll that exceeds it shows that it does instead of being quietly rescaled.
Read from the 32 most recent posts we hold, published 24 July 2026 to 11 August 2026. Telegram labels each poll by kind — an anonymous poll, a quiz, a closed set of final results — and that label is reproduced rather than paraphrased.
Forward network
Republished by
Channels on the register that have forwarded this channel's posts into their own feed.
Built only from forwarded posts we have actually read, on both sides. Coverage is early and deliberately incomplete: a missing link means we have not read the post that would prove it, never that the relationship does not exist. Counts are distinct forwarded posts observed, so they only ever go up as we read more.
Mentions
Named by 2 registered channels — every channel on the register whose own posts have named this one, by its current username or any other username it currently holds, merged from two separately captured readings of the same fact so a namer caught by only one of them is not missed and a namer both caught is not counted twice. A username this channel has since dropped is not matched — that handle may belong to someone else now, and crediting today’s namer to yesterday’s owner would misattribute it.
Named by
Channels on the register whose posts name this channel's handle.
A mention is a weaker signal than a forward and is counted separately for that reason — naming a channel is not republishing it, and a handle in a post body is easy to place deliberately. The post counts beside each row below are distinct posts in which the handle appeared, from posts we have read on both sides — the “Named by N registered channels” figure above is a different count, of distinct NAMING CHANNELS rather than posts, and is not the sum of the rows under it.
Appears in Telegram’s recommendations for other channels
The reverse of the list above, and a different kind of signal. This does not require this channel to have ever been asked about directly — each row below is a channel we DID ask Telegram about, whose Telegram-generated list happened to include this one. A channel can appear here with an empty list above it, because being named by someone else’s query is independent of having been queried itself.
@anchabaranova · 35,609
Telegram ranks this channel #5 of 98 here — alongside 97 others — read 2 September 2026
This channel appears in 1 seed channel's Telegram-generated recommendation list in total. Each is Telegram’s list for THAT channel, not this one — see how this is measured.
Cite this entry
A live page changes as we take new readings, so a citation should name the measurement it is based on, not just the URL. The line below cites the subscriber count as measured 10 September 2026 — this entry's latest reading, not the date you are reading this.
“Significo-АМГ” (@significogene), 5,746 subscribers as measured 10 September 2026. Telegram Register, tgregister.com/channel/significogene.
Full measurement history, CC BY 4.0. Every reading this register holds for this entry, not just the latest one, as a dated, downloadable record: CSV · JSON. Free to use with attribution to tgregister.com. Each file carries its own generation timestamp, which is the figure to cite for exactly when the data was retrieved.